Mechanisms of action of anti-cancer monoclonal antibodies. The Weiner Laboratory has a long-standing interest in the mechanisms of action of anti-cancer antibodies, with a particular focus on the complex interactions between complement fixation and antibody dependent cellular cytotoxicity. The goal of this research is to identify approaches to designing more effective anti-cancer monoclonal antibodies.
RNA aptamers and cancer immunotherapy. The newest area of research in the Weiner laboratory is based on a collaboration with Dr. Paloma Giangrande and involves the selection and analysis of RNA aptamers designed to modify the anti-cancer immune response.